In the course of a review of Rosenow’s 1955 detailed article discussing the etiology, diagnosis and treatment of diverse diseases, the writer was particularly struck by his reported findings relative to infections in reproductive organs.  The “new” information presented in 1955 was the extent to which the issue concerned all of both the males and females in his study.  It is particularly striking that (beyond and in agreement with his prior work involving only females) in all three of three couples tested in this manner, plus one male, and reported in this study, all four males and all three females exhibited compromised fertility due to infection.

In agreement with Rosenow’s findings, Dr. Sami David’s modern book Making Babies, discusses in depth his own direct experience with couples seeking assistance, indicating that both sexes are apparently an equal factor.  According to Dr. David, the cause of infertility is 40% female, 40% male and about 20% combined.  In a recent (May 9, 2013) episode of the American Health Journal (http://www.discoverhealth.tv/show482.html, 8:11 – 12:35), Dr. David asserts “It’s not fair that these women are taking the brunt of all the infertility and miscarriages on themselves.  The husband is a major issue, as much as the woman is.”  Defining infertility as not being able to get pregnant after one year of trying, or 6 months if a woman is 35 or older, Dr. David cites a number of examples of successes.  For example, one couple had spent $100,000 on treatments on the woman, whereas simple antibiotic treatment of an infection in the male partner resulted in prompt success in fertilization and birth. 

Also implicating an infectious etiology, while focusing solely on the female component of reproduction, is the distinctly separate work of Dr. Luiz Moura of Brazil, who has reported on the successful use of autohemotherapy (the intramuscular reinjection of freshly drawn autologous blood) in a wide range of conditions.  Dr. Moura’s use of autohemotherapy in overcoming difficulty in conception, with his own daughter as a prime example, in a sense confirms the Rosenow indication of the presence of an implicated causative organism in the blood; the intramuscular reinjection of the implicated organism (within the blood) in effect seemingly serves as a vaccine against the harmful effects of that organism.  However, Dr. Moura did not refer to treatment of the male partners of couples experience reproductive issues.

Accordingly, it may be readily assumed, consistent with the works of Rosenow and David, that prospects of replicating Moura’s reported successes with autohemotherapy could be further enhanced through its use by both female and male partners.  Further, in view of the generally beneficial effects on any and all disease conditions being disseminated via the bloodstream (and general absence of ill effects), the relatively inexpensive method of autohemotherapy might be employed immediately, while other investigations into possible problem areas are being initiated/ explored.

Appendices below are summary statements / excerpts on this subject from

(A) Dr. Luiz Moura and (B) Dr. E.C. Rosenow; and (C) provides recent related bibliographical items from a compilation kindly provided by Dr. Robert Gammal (RobertGammal.com).

 (A)  Auto-Hemotherapy, Contribution to Health -- Dr. Luiz Moura (http://instituteofscience.com/MouraDVD.htm ): A Transcript of 2004 testimonial videos available on Youtube.com.  Transcript kindly provided by Arsenio Fornaro as translated by
Campanha Nacional em Defesa da Auto-Hemoterapia - Participe! É Legal! (Constituição Federal: artigo 5º, II, IV e IX).

The work of Moura provides a simple method of addressing the situation (even without addressing the oral source /”nest” of infection issue implicated by Rosenow).  Moura’s successful report regarding his daughter and several other instances would logically be enhanced, in accord with Rosenow’s findings, by treating both of respective partners with autohemotherapy.  While Moura used a weekly method of application, Rosenow’s preferred method of vaccine-therapy, as illustrated in his latest articles, was bi-weekly.  In the case of autohemotherapy, which would have to suffice in lieu of a proper autogenous Rosenow vaccine, a more frequent than weekly regimen might  likewise be implicated in order to maximize production of time-specific antibodies (against whatever phase or strain of causative organism is in the blood at any particular time), e.g., bi-weekly or even more often.

Dr. Moura:  “Ovarian cysts and myoma:  My daughter who lives in Spain was sterile; she had polycystic ovaries and was not able to become pregnant. Her obstetrician delivered her two children  He applied auto-hemotherapy to her and six months later she had no more cysts. The Immune System had devoured the cysts, had eliminated the cysts, and she became pregnant for the first time.

“After she became pregnant for the second time, and for just over twenty years, she has used the IUD so as not to become pregnant anymore. Then the problem was reversed. Before she had been sterile, but later on she had to use IUD to avoid becoming pregnant again, because she was already happy with a boy and a girl. I have two grandchildren there, my grandson is 23 and my granddaughter 21, she is an agronomist and my grandson works with image and sound. Later on I used it on patients over here, in many cases of ovarian cysts and myoma as well. The myoma is devoured by the Immune System, so it is really something of enormous value and I hope that now it will have a wider dissemination.”

(B)  E.C. Rosenow, “Specific types of alpha streptococci in the etiology and streptococcal thermal antibody in diagnosis and treatment of diverse diseases”, J Nerv and Mental Dis 122 (1955), 238-247. 

Particularly striking in Rosenow’s localization experiments (in lab animals), infertility is associated with both men and women, with number of colonies of infertility-associated organisms in two tests in males (78 and 68) larger than in females (58 and 41) and larger than any of 9 other disease categories, although specificity percentages for males (50 and 36) were smaller than percentages for females (78 and 55), as discussed/explained below.  No other disease categories were close in terms of numbers of colonies or percentages, nothing over 20 colonies or 20%, except for myasthenia gravis (60 colonies and 32%).

The universal lower motility of all four males in the study, which combined with the findings in females, suggests that infertility may in some cases if not generally be result of infection in both male and female of infertile couples.  In other words, even in cases where female fertility is reduced, it is possible that infertility in involved couples may also involve reduced male fertility, whereas in such cases amelioration involving females only, either through autohemotherapy as reported by Moura, or via the likes of modern fertility enhancement methods, might nonetheless often be sufficient to overcome the problem.

p. 210   “A truly remarkable elective or specific localization occurred in organs of mice corresponding to those chiefly involved in patients from whom the streptococcus was isolated from the nasopharynx in each of  [several disease conditions including ] … diseases of unknown etiology and currently not generally considered as due to infection … [including] infertility in otherwise well male and female persons  ...”. …

    “Three childless married couples and one other married man, all in good health, ranging from 25 to 32 years in age who desired children were studied from the standpoint of the possibility that a specific symptom-less streptococcal infection or intoxication having predilection for the reproductive organs, the testicle in the male and ovary in the female, might conceivably be responsible for such infertility.  In the case of the female sex, such a possibility was indicated years ago when pure cultures of alpha type streptococci were isolated from surgically removed cystic ovaries of infertile excessively nervous married women.  These streptococci were shown to have predilection for the ovary of rabbits on intravenous injection. [Rosenow EC and Davis CH, JAMA 66, 1175-80, 1916]

    “Each of 7 persons, 4 males and 3 females, studied in the infertile group was pronounced normal physically by their respective urologists and gynecologists.  The motility of spermatozoa in the semen of the males was found deficient. All 7 persons appeared and felt well at the time of my study.  The streptococci that grew from the nasopharyngeal swabbings at the end point of growth in serial dilution cultures in dextrose brain broth were injected intravenously into altogether 67 mice in the usual manner (table 1).  The mice remained apparently well and as in the other groups were etherized to death 20 to 24 hours after the respective injections. Cultures of testicle and ovary of the inoculated mice yielded pure cultures of the streptococcus in far higher numbers and incidence than did the other organs following injection of the streptococci from both infertile males and females.  The isolations of streptococci from the testicle of mice following injection of the streptococcus from infertile males (68; 36% =  number of colonies; percentage of isolations) were somewhat higher than isolations following injections of streptococci from infertile females (41; 55%).  Isolations from ovary were somewhat greater following injection of the streptococci from infertile males (78; 50%) than following injection of streptococci from infertile females (58; 78%).  Isolations from other organs in the infertility group were minimal throughout.  Moreover, isolations of streptococci from the testicle or ovary of mice receiving the streptococcus from sources other than the infertile group (with but one exception, myasthenia gravis) were far less than in mice receiving corresponding injections of streptococci from the infertile group.”

    For comparison, in each of twelve other conditions (glaucoma, chorioretinitis, epilepsy, schizophrenia, multiple sclerosis, epidemic poliomyelitis, coronary heart disease, respiratory infections, arthritis, myasthenia gravis, muscular dystrophy, infectious mononucleosis, but excluding Myasthenia gravis), numbers of isolations in ovaries or testicles ranged from 0 to 20 and percentages from 0 to 20 (except Myasthenia gravis, with 68 and 32%).  Other test:  Diagnostic cutaneous reactions to homologous antibody, for infertility, were 13.30 compared to 9.01 for respiratory infection and 9.83 for arthritis; and specific agglutination of alpha streptococci was 50% for infertility group, versus 0 to 20% for the several other groups listed (except muscular dystrophy, 34%).  These latter categories were not shown for male versus female.

     “SUMMARY AND COMMENTS  --  The number of streptococci and the percentage incidence of isolations from the organs of the inoculated mice corresponding in the ones affected the respective patients were uniformly far greater than from organs not affected except from the lesion-free liver, spleen and kidney representing perhaps a scavenger-like function of these important massive organs.  Causal relationship of the streptococci isolated from the nasopharynx in the diverse diseases studied is indicated by (1) their localizing maximally in the organs of mice on intravenous injection corresponding to the respective tissues or organs chiefly affected in patients from whom isolated, (2)  by the diagnostic erythematous cutaneous reactions on intradermal injection of the respective streptococcal thermal antibody solutions, and (3) by the specific agglutination of the respective streptococci by the corresponding streptococcal thermal antibody. … [citing previous publication on transmutation]  “it is likely that the respective specificities of streptococci in these naturally-occurring diseases are acquired or develop in the respective hosts. Since the conditions in some of the patients had persisted for several years and the general health was not greatly impaired, it almost seems that the persons ill with such chronic localized diseases supply the very physicochemical or other conditions under which the indigenous streptococci normally present in the throat of human beings acquire and maintain respective specific organotropic properties.” [Rosenow EC and Heilman FR, Proc.Soc. Exper. Biol. And Med 34, 419-425, 1936]

(C)  Recent related bibliographical items compiled by Dr. Robert Gamal:

Paquette DW   The periodontal infection-systemic disease link: a review of the truth or myth. J Int Acad Periodontol (2002 Jul) 4(3):101-9

Other citations referring to reproductive system relative to oral infections (1998-2011)::

Okuda K  Ebihara Y  Relationships between chronic oral infectious diseases and systemic diseases. Bull Tokyo Dent Coll (1998 Aug) 39(3):165-74

Dasanayake AP. Poor periodontal health of the pregnant woman as a risk factor for low birth weight     Annals of Periodontology 1998 July; Volume 3, Number 1, pp. 206-212.

Offenbacher S, Jared VIL, O'Reilly PG, Wells SR, Salvi GE, Lawrence HP, Socransky SS, Beck JD. Potential pathogenic mechanisms of periodontitis associated pregnancy complications.   Annals of Periodontology 1998 July; Volume 3, Number 1, pp. 233-250.

Scannapieco FA  Position paper of The American Academy of Periodontology: periodontal  disease as a potential risk factor for systemic diseases. J Periodontol (1998 Jul) 69(7):841-50

Champagne CM  Madianos PN  Lieff S  Murtha AP  Beck JD  Offenbacher S  Periodontal medicine: emerging concepts in pregnancy outcomes. J Int Acad Periodontol (2000 Jan) 2(1):9-13

Joshipura K  Ritchie C  Douglass C  Strength of evidence linking oral conditions and systemic disease. Compend Contin Educ Dent Suppl (2000)(30):12-23; quiz 65

Periodontal disease and systemic disease. Clinical information for   the practicing dentist.  J Indiana Dent Assoc (2002 Summer) 81(2):15-8

Lavelle C   Is periodontal disease a risk factor for coronary artery disease   (CAD)? J Can Dent Assoc (2002 Mar) 68(3):176-80

Pryszmont J  Grygorczuk S  Kondrusik M  Pancewicz S  Zajkowska J   Severe form of odontogenic sepsis--a case report  Pol Merkur Lekarski (2005 Mar) 18(105):314-6

Scannapieco FA   Systemic effects of periodontal diseases.  Dent Clin North Am (2005 Jul) 49(3):533-50, vi

Han YW  Fardini Y  Chen C  Iacampo KG  Peraino VA  Shamonki JM     Redline RW   Term stillbirth caused by oral  Fusobacterium nucleatum.  Obstet Gynecol (2010 Feb) 115(2 Pt 2):442-5

Hobson DT  Imudia AN  Soto E  Awonuga AO   Pregnancy complicated by recurrent brain abscess after extraction of   an infected tooth. Obstet Gynecol (2011 Aug) 118(2 Pt 2):467-70   (Copy in Brain, Reproduction Section)