RE: Book proposal Infectious Etiologies of Neuropsychiatric Disorders
Thursday, June 13, 2002 12:21 AM

From: "S H Fatemi" <S-Houssein,>
To: "S.H. Shakman" <shshakman@YAHOO.COM>


Dear Dr.Shakman:
Thank you very much for your kind remarks on my book proposal.Indeed ,if this proposal is accepted,I would appreciate if you  could agree to contribute a chapter to it. 

 [Chapter as drafted for (subsequently-cancelled) Wiley book: Shakman-History-Rosenow.pdf]

----Original Message-----
From: S.H. Shakman []
Sent: Monday, June 10, 2002 11:29 PM

Subject: Re: Book proposal Infectious Etiologies of Neuropsychiatric Disorders

 Dear Charlotte Brabant

Thank you for contacting me regarding Dr. Fatemi's book proposal, "Infectious Etiologies of Neuropsychiatric Disorders".
Thanks also to Dr. Fatemi for the courtesy of soliciting my opinion. My relevant perspective builds on experience as a (former) health program analyst for the U.S. State Dept. (AID) and science researcher (‑456.html), and specifically is based primarily on subsequent intensive analysis of the microbiological works of the late E.C. Rosenow, M.D. (1875-1966). As the Mayo Foundation's longtime head of experimental bacteriology (1915-44), Rosenow compiled compelling direct evidence of an infectious etiology (substantially satisfying and additional to Henle-Koch criteria, e.g., see for a range of systemic conditions, including diseases of the nervous system. His work included reference to a number of conditions mentioned in Dr. Fatemi's proposal, i.e., encephalitis, herpes, influenza, meningitis, mental deficiency, schizophrenia, syphilis and Tourettes. Rosenow concentrated on epilepsy, schizophrenia and closely related disorders for over a decade following his retirement from Mayo, building on decades of experience with other nervous system diseases, as summarized in my 2001 Stanley Symposium abstract and associated presentations: (,
 & (

Notwithstanding its currently obscure status, Rosenow's microbiological work is monumental, consistent and seemingly impregnable, and thus arguably conclusively-supportive of a modern consensus that infection is involved in the cause of schizophrenia. As such, it is somewhat amazing and a tribute to the instincts of its advocates of the modern view that it has been able to evolve so far in this direction wholly independently of Rosenow's documentation of microbiologic specificity. At the same time, while the modern view does not build on Rosenow, neither does it contradict nor supercede him.

Regarding your questions:

1. Is there, in your opinion, a need for a publication of this type?
Yes. The above-described historical-bacteriological view provides substantial independent support for such a publication, at a minimum, as well as for the overall concept of involvement of infection in the cause of schizophrenia and closely related disorders. However, even without such support, publication of a book featuring the modern view would still be appropriate.
The modern view on the role of infection in schizophrenia and related neuropsychiatric conditions, as incorporated within Dr. Fatemi's proposal, indisputably represents a fundamental shift in thinking that has occurred within recent years, encompassing psychiatry and psychology. This shift has been characterized by U.S. Surgeon-General David Satcher as a "revolution in science" (; and is prominently reflected in the U.S. NIMH position on the cause of schizophrenia: "scientific theories suggest there is a genetic component, possibly combined with an exposure to infections either in the womb or during early childhood" ( From a historiographic perspective alone, considering the dominance of the Freudian-influenced view over much of the 20th Century, this is a big story that certainly merits book-length treatment.
In a sense Rosenow anticipated the modern view with his reference to causality by infection in combination with inherited or inherent conditions (which he concluded may themselves contribute to specifity, not merely vulnerability; e.g., see, except that his emphasis was on later infections rather than prenatal or other early ones (although he did document possible prenatal passage as discussed below in para. 3).

2. Do you think that the proposed book would fulfill such a need, if indeed one exists?
Yes. Dr. Fatemi's roster of contributors seemingly guarantees that the predominant works associated with the modern view of schizophrenia, as relates to infectious hypotheses, will be comprehensively represented.

3. Please comment on the (a) content of the book and its scope. Are there any obvious (b) gaps and/or areas that you would wish to see covered in greater detail? Have you any (c) other editorial suggestions which you feel might improve the usefulness and value of the proposed book?
Two fundamental areas addressed in Dr. Fatemi's proposal might be further amplified, with corresponding revisions reflected as appropriate elsewhere in the proposal: (1) separation of consideration of incontestably-developmental disorders from others, as indicated by separate treatment of autism in Dr. Fatemi's outline; and (2) explicit consideration of types of infections other than pregnancy- or birth-related infections, e.g., items in Dr. Fatemi's definition of topic and proposed outline.

(1) Separation of Incontestably-Developmental Disorders from Hypotheses
Dr. Fatemi's separation of consideration of autism within a separate chapter seems appropriate and might be made even more distinct, although it is acknowledged that NIMH and others tend to group autism within listings of neurological disorders including schizophrenia, the term "autism" was originally used by Bleuler, 1908, as a characteristic of schizophrenia (, and Dr. Fatemi's own work relates to both autism and schizophrenia.  Fundamental issues concerning autism and other conditions that are indisputably developmental (with or without neuropsychiatric manifestations) are different from those concerning disorders for which developmental origins are not established. In the case of autism, the question seems to be not whether a developmental insult occurred, but rather what was its nature. In the case of disorders that are hypothesized but not yet established to be developmental, the task of determining the validity of any sort of developmental origin is itself fundamental.

Although there is logic for coordinating assessments of possible effects of developmental infections on both categories, and this information may even become decisive in determining the extent to which a given disorder in the undecided category may be developmental, careful and separate consideration may help avoid possible confusion by association.

In this same vein, it would seem prudent to similarly separate out other special cases from consideration of the issue as to whether, and to what extent, "typical" adult-onset schizophrenia may have developmental roots. From this perspective, the finding that some schizophrenics have minor physical anomalies or other congenital abnormalities seems less an argument that schizophrenia is developmental and more an argument that those with the likes of congenital abnormalities be excluded from examination of this issue (i.e., developmental or not) as relates to the cause of adult schizophrenia. Such separate consideration would also be seemingly indicated in the case of not only multi-dimensionally impaired children but also childhood schizophrenia in general, so as to assure maximally-objective assessments of causation for each involved category.
From this standpoint, an alternate organizational approach based on type of condition may be preferable; however, regardless of final organizational scheme, specific provision might be made in the outline for overview discussions of cross-cutting topics or analyses, e.g. the nature of Dr. Fatemi's own research.

(2) Consideration of Types of Infections Not or Not-Necessarily Related to Pregnancy or Birth
While issues related to prenatal, etc. insults are of paramount importance in considering decidedly-developmental conditions, some broader or other means of categorization seems appropriate in the case of schizophrenia etc. Estimates of how much schizophrenia may be developmental in origin range from "half or more" ( to "only a minority" ( or one subgroup ( Either position allows that at least some schizophrenia is not developmental, seemingly calling for some degree of explicit attention to the issue and specifics of the possible relation of schizophrenia and other neuropsychiatric disorders to infections that are independent of developmentally-related events.

Accordingly the concept of non-developmental adult-onset schizophrenia, as well as the likes of adult-onset conditions listed by Dr. Fatemi in definition of topic and proposed contents, e.g. Parkinson's and psychosis after adult onset influenza, might be placed in an "other" or "adult" category so as to allow for consideration distinct from (typically-immediate) post-natal events.

Such an "other" category is also supported by other circumstantial evidence of infectious involvement without reference to birth-related events. For example, according to Dr. Fatemi's proposed co-author Dr. Torrey, "There is some evidence that individuals with schizophrenia have more infections, heart disease, type II (adult onset) diabetes, and female breast cancer" (per Such a circumstance may be taken to suggest a direct relation between infectious agents in schizophrenia and these other conditions, as also may be indicated in the above-mentioned association of psychosis and influenza, etc. In addition, similar geographic patterns of schizophrenia and MS, and similar results of twin studies for schizophrenia, MS and polio, as discussed by Drs. Torrey and Yolken (,schizo%20bipolar.pdf), are at least suggestive of involvement of similar infectious processes (e.g. as directly addressed by Rosenow and associates).

Additionally, the direct nature of adult onset neuropsychiatric symptoms associated with several infectious diseases as per Dr. Fatemi's definition of topic, in contrast to the indirect nature of hypotheses involving early insults and later symptoms, conceptually argues for: consideration of possible more general applicability of the former (more direct) mechanism; and specific discussion of justification for exploring special infectious mechanisms to explain neuropsychiatric disorders, as distinct from general infectious mechanisms under consideration in other areas of medicine.

Further, it is noted that the modern view understandably embodies component hypotheses that may themselves be in conflict. D.R. Weinberger, a key advocate of the neurodevelopmental model for schizophrenia (, has noted "a surprisingly large number of investigations over the past three decades" into obstetrical complications as possibly contributing to schizophrenia, and has suggested that validation of a prenatal connection could make obstetric complications "irrelevant". He also indicated that this could make explanation of delayed onset problematic, due to the "unlikely scenario of a secondary primary pathology". (This reasoning might also place the modern view in conflict with Rosenow's distinctly later-onset ostensively-primary pathology.) In any case, the challenge of explaining the presumed latency period, between proposed early insult and late onset of schizophrenia, etc., seems also deserving of special attention and specific mention in the final book outline.

Moreover, as per Weinberger and elsewhere, Torrey has expressed doubts about a relation between schizophrenia and: mother's influenza during pregnancy (, and early childhood viral nervous system infections (

These widely acknowledged controversial circumstances seem to call for special efforts to comprehensively incorporate critical assessments of the modern perspective, as well as its component hypotheses, so as to avoid any possibility of being perceived as a partisan endeavor.
It may be noted incidentally that Rosenow seems to have documented prenatal passage of infection as conclusively as possible, in the case of epilepsy, as this involved an infectious agent injected into a pregnant rat and seemingly passed to one of four offspring, which agent was then recovered from the affected offspring and passed to other animals (

Hippocrates also briefly mentioned possible ill-effects of in-utero infection, this as related to season of birth, within paragraph 12 of Aphorisms Section III. This involved scheduled delivery in a dry Spring following a mild Winter, which was associated with possible spontaneous abortion or immediately-evident feeble offspring. However, his overwhelming emphasis (i.e., 22 other paragraphs) involved more direct considerations of seasonality of onset of disease, e.g., associations between rainy seasons and arthritis, Winter and pneumonia, Spring and maniacal, etc.

Rosenow also addressed seasonality of onset with reference to infection, e.g., involving infective agents isolated in studies of schizophrenia (, violent criminality (, stomach ulcers (, and effects of solar radiation on seasonal change in specificity (

The modern perspective on seasonality has primarily focused on studies of season of birth, with reference to the above-cited Hippocratic observation and the possibility that infectious agents may contribute to reported winter-spring excess of births for schizophrenia and other conditions ( Modern researchers also deal with seasonality of onset with reference to seasonal affective disorder (SAD), a condition that is helped by light therapy. However, in that geographic incidence of SAD is similar to MS and schizophrenia, and light therapy also has been found to help with some non-seasonal disorders (, possible involvement of an infectious component for SAD might merit consideration.

Rosenow's methodology might be of service in shedding some light on this and other questions concerning the possibility of specific infection related to schizophrenia. For example, he found close correlations between schizophrenia and some psychoneurotic and psychophysiologic disorders in terms of agglutinative titer of blood serum, in sharp contrast to negative results for well controls and chronic brain syndromes due to syphilis. He also found surprisingly strong indications of specificity (for an infectious agent isolated from schizophrenia) in cases of "mental deficiency" (, implying that such a condition might be amenable to correction through specific vaccination, etc.

Of course, the bottom line on any sort of correlations is that they do not in and of themselves cause diseases or prove causation. As emphasized by Dr. Torrey at the conclusion of his recent book, The Invisible Plague, p. 333: "The challenge, therefore, is not only to identify correlations but also to prove that they have some causal connection to insanity." In this regard, the continuing relevance of Koch's classic standards for proving causation by infection has been prominently emphasized by Dr. Yolken (per Carl Zimmer, Science 293, p. 1977, 14 Sept. 2001). The Rosenow perspective is wholly in accord with Drs. Torrey and Yolken on this point, emphatically asserting that and demonstrating how these criteria can indeed be fulfilled, even for chronic diseases like schizophrenia.

4. Please comment on the author's standing in and contributions to the field. Are you familiar with the author? Do you think this author is well-suited to writing the book as proposed?
Dr. Fatemi seems well positioned to serve as principal editor based on his familiarity with the contemporary neuropsychiatric research perspective and community, openness to the historical perspective, and the distinctly independent quality of his own work.

5. What do you consider to be the primary markets for this book? In your opinion, is this book primarily a reference, text or monograph? NA

6. Are there any undergraduate and/or postgraduate courses NA

7. Do you know of any existing publications on this subject or manuscripts in preparation which are likely to compete with the book under review? Please supply details and compare principle features.
Some works with which I am associated also deal with the subject of the relation between infection and neuropsychiatric disease. They are not competitive in that they do not refer to the modern position; however, they do deal with the same end. Information copies of some of these materials have been sent to Dr. Torrey over the past year, in an effort to make their existence known to modern researchers. Under separate cover I will be sending a copy of them to you, and would welcome discussion of any interest you may have in making them available on a broader scale.

8. Could you suggest possible additional referees? (Please provide full addresses and/or telephone numbers where possible) NA

9. Are there any additional comments you wish to make concerning the proposed book? NA

10. In the event of any discussion of your comments with the author(s) and/or editor(s), do you have any objection to the disclosure of your identity, or would you prefer to retain reviewer's anonymity?

Please feel free to discuss these comments with Dr. Fatemi; in any case I am sending him a copy, insofar as my above-cited 2001 Stanley Symposium presentation materials, as submitted but not yet posted on Dr. Torrey's website, has not otherwise been available to him. (He has seen the abstract as printed in a book distributed at the symposium.) I sincerely hope this information will serve him constructively.

A courtesy copy is also being sent to Dr. Torrey, in that his work is prominently cited herein, and also in appreciation for the vehicle of his 2001 Stanley Symposium which indirectly enabled this contact.

With kind regards,
S. H. Shakman, Ph.D.
Institute Of Science
cc. Dr. Fatemi, Dr. Torrey  


Initial email request from Wiley (London) for review Fatemi book proposal; inluding:
-- Fatemi book proposal
-- review questionnaire




Date: Thu, 28 Mar 2002 14:37:32 +0000

Subject: Book proposal Infectious Etiologies of Neuropsychiatric Disorders

Dear Dr. Shakman,

Please allow me to introduce myself as Senior Publishing Editor in the Life & Medical Sciences at John Wiley & Sons. I am responsible for our publishing programme in psychiatry and neuroscience and wondered if I might presume to ask a favour. I am currently considering a proposal for a new book titled Infectious Etiologies of Neuropsychiatric Disorders to be edited by S. Hossein Fatemi.

Given your expertise, I would be most grateful if you could take a few moments from your busy schedule to review the attached proposal from the author outlining the contents and scope of his book. I have also attached a reviewer questionnaire to help you frame your comments. In exchange for your efforts, I am able to offer you a modest honorarium in the form of Wiley Books up to the value of 75/$100.

I am keenly interested in your opinion on whether this book would be a valuable addition to the literature and, if so, what it would ideally contain. What do you think of its proposed scope and coverage? To whom do you think it will most appeal? Do you think it correctly identifies its target market? Are you familiar with the editor? I would also be interested in your views on how this book compares with competing volumes.

If you have any questions, I would be happy to provide additional information; please don't hesitate to contact me.

Thank you in advance for your assistance; I look forward to receiving your comments shortly.

Until then, best wishes

Yours sincerely

Charlotte Brabants
Senior Publishing Editor
Life & Medical Sciences
Tel: +44 (0) 20 8326 3842

(See attached file: fatemi propsosal.doc)
(See attached file: Fatemi REVQUES.doc)



Tentative book title and subtitle (if any): Infectious etiologies of neuropsychiatric disorders

1. Author's/Editor's full name: S. Hossein Fatemi, M.D., Ph.D.
2. Position and Affiliation: Associate Professor of Psychiatry, Cell Biology & Neuroanatomy, Adjunct Associate Professor of Neuroscience
3. Full Mailing addresses: Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical Center, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
4. Telephone: 612-626-3633
5. Please list details of co-author(s) and their affiliations:
Co-editor, Dr. R. A. Machon
Professor of Psychology
Loyola Marymount University
Potential co-authors:
Dr. S. Mednick, University of Southern California
Dr. E. Fuller Torrey, Stanley Foundation
Dr. R. Yolken, Johns Hopkins University
Dr. M. Pletnikov, Johns Hopkins University
Dr. K. Lieb, University of Freiburg
Dr. S. Swedo, NIH
Dr. S. Brown, Columbia University
Drs. P. Wright & R. Murray, Institute of Psychiatry, London
Dr. R. Firouzi, University of Laennec, France
Dr. S. Kim, University of Minnesota


6. Definition of topic
Recent immunologic, epidemiological, microbiologic and neuropsychiatric studies point to infectious etiologies of several important neuropsychiatric disorders e.g. schizophrenia, autism, obsessive-compulsive disorder, depression & Tourettes disease. Additionally, several infectious diseases including human influenza virus, HIV, syphilis, Lyme disease are associated with neuropsychiatric symptoms following transmission of infectious agents to the central nervous system of the adult individuals. Accumulation of experimental evidence also points to potential for peri-, pre- and postnatal infections as causes for several neurodevelopmental disorders such as schizophrenia, autism, cerebral palsy and mental retardation.

7. Please write a short description of your book which could be modified for promotion purposes.
This comprehensive and integrative book examines the role that infectious agents play in the etiology of various neuropsychiatric disorders, including schizophrenia, autism, mood disorders and obsessive-compulsive disorder. Recent advances in technology and methodology now afford a meaningful examination of the infectious etiologies of neuropsychiatric disorders. Drawing on the contributions of an international panel of experts, this work provides an unprecedented analysis of this emerging field by examining evidence from epidemiologic, serologic and animal models.

8. Please outline your reasons for proposing a new book in this area:
A. near absence of a comparable book in the literature
B. availability and readiness of a group of selected experts in the field to contribute to this book
C. availability of state of art data collected over recent years
D. presence of clinical data pointing to infectious etiologies for certain neuropsychiatric disorders
E. presence of experimental data from animal models providing convincing information on role of infectious agent causing brain disorders

9. Please list major features of your book which make it unique:
This book is the first serious attempt at enumerating experimental and clinical data regarding the infectious etiologies of several important neuropsychiatric disorders such as schizophrenia, autism, mood disorders and obsessive-compulsive disorder. Features which make this book unique is the expertise of the authors of this book; additionally, presented data are products of years of laboratory and/or clinical studies which have been published in refereed journals.

10. Please list proposed contents, including section and sub-section headings
(possibly attach a separate document)
I. Introduction to infectious etiologies of neuropsychiatric disorders
II. Prenatal viral infections and schizophrenia
A. Epidemiologic data on influenza
B. Epidemiologic data on rubella
C. Serologic data on herpes
D. Serologic data on influenza
E. Animal models
i. mouse model of human influenza viral infection
structural and protein data
behavioral data
III. Prenatal infections and autism
A. Epidemiologic data
B. Serologic data on rubella
C. Animal models
i. influenza
ii. Borna disease
iii. Choriomenigitis
iv. CMV

III. Postnatal infections and psychiatric disorders
A. Epidemiologic data
B. Serologic data on OCD and streptococcus
C. Adult Borna disease and mood disorders
D. Von Economo's encephalitis, Parkinson's and psychosis after adult onset influenza

IV. Conclusion

11. Approximately how many pages, would you expect your book to contain? 200-300

12. How long do you estimate it will take for delivery of the completed manuscript? 8 months

13. Will you be able to prepare your manuscript on a word-processor? Yes

14. If so, what software will you be using? Microsoft Word 98

15. Please list any special physical features you would expect to include:
Tables, illustrations, photographs


16. Please identify the readership for your book:
16.1 Primary Market: Psychiatrists, neuroscientists, scientists, neurologists, infectious disease experts
16.2 Secondary Market: graduate and medical students

17. Please indicate any societies, professional organizations, companies or other groups which might want to know about your book:
American Psychiatric Association (APA)
Society for Neuroscience
American Medical Association
Biological Psychiatry
American College of Neuropsychopharmacology
Cure Autism Now
National Alliance for Research in Schizophrenia and Depression

18. Please list any key journals in this area and any major conferences:
Journals Conferences
American Journal of Psychiatry Biological Psychiatry
General Archives of Psychiatry American College of
Biological Psychiatry Neuropsychopharmacology
Molecular Psychiatry APA
J Autism & Developmental Disorders Society for Neuroscience
Neurology International Meeting for
Neuroimmunology Autism Research
Neurovirology NIH (NIMH, NIDR, NINDR, NICII)
Proceedings of the National
Academy of Sciences
New England Journal of Medicine
Schizophrenia Research

19. For what specific courses is your book written? The book is aimed primarily at psychiatrists, neuroscientists, and neurologists and secondarily at graduate students and medical students dealing with pathophysiology and neuropsychiatric disorders.
19.1 Level: Scientists
19.2 Typical student numbers: 150-200 medical students/per class
19.3 Length of course: 1 semester
19.4 Is the course optional or compulsory? Optional
19.5 Would your book be for main adoption, supplementary reading or recommended reading? Supplementary or recommended reading
19.6 Can you suggest any lecturers who would be particularly interested in hearing about your textbook?
19.6.1 In Europe
19.6.2 Dr. R. Murray
Dr. P. Falkai
Dr. Bogerts
19.6.3 In North America
Dr. D. Pearce, Emory University
Dr. Srivastava, McGill University
Dr. D. Weinberger, NIH
Dr. B. Lipska, NIH
Dr. P. Patterson, Cal Tech
Dr. I. Lipkin, Cornell
19.6.3 Elsewhere

20. By what percentage has this new edition of your book increased/shortened? NA
21. Has your approach to the subject changed considerably from the previous edition? If so, how? NA
22. Please list up specific changes/differences between the old and new edition of your book and how these changes will enhance this edition: NA

23. Please list in order of importance, any existing books which are related toy our book. Please supply 9ifpossible) author/editor, publisher, publication data, price and any further information you feel relevant.
There are currently, no published books exclusively dealing with this topic in the market; however, a book entitled "Prenatal Exposures in Schizophrenia" edited by Susser ES et al (APA, 1999) has two chapters dealing with infectious etiologies of schizophrenia.

24. Please outline in what ways your book is better than and differs from the titles mentioned in previous section. NA


25. Please give an international list of persons qualified to give an opinion on your book proposal:
1. Dr. N. Muller, Ludwig-Maximillan University, Germany
2. Dr. J. Blomberg, Academic Hospital, Uppsala, Sweden
3. Dr. S. H. Shakman, Institute of Science, California
4. Dr. E. Marcotte, McGill University
5. Dr. P. Harrison
6. Dr. D. Pearce, Emory University
7. Dr. M. Hornig, Cornell University
8. Dr. N. Weatherall, Viromed Laboratories, Inc., Minneapolis
9. Dr. J. S. Oxford, St. Bartholomew's and the Royal London School of Medicine & Dentistry
10. Dr. M. Ison, University of Virginia
11. Dr. F. G. Hayden, University of Virginia
12. Dr. A. Patick, Agouron Pharmaceuticals, Inc., california
13. Dr. K. Shortridge, University of Hong Kong



Review of New Book Proposal
Edited by S. Hossein Fatemi


Price Pages Illustrations
Approx 75 250 pp Yes
Anticipated Pub Date
December 2003 Hardback

1. Is there, in your opinion, a need for a publication of this type?

2. Do you think that the proposed book would fulfil such a need, if indeed one exists?

3. Please comment on the content of the book and its scope. Are there any obvious gaps and/or areas that you would wish to see covered in greater detail? Have you any other editorial suggestions which you feel might improve the usefulness and value of the proposed book?

4. Please comment on the author's standing in and contributions to the field. Are you familiar with the author? Do you think this author is well-suited to writing the book as proposed?MARKET FOR THE BOOK

5. What do you consider to be the primary markets for this book? What are the potential secondary markets and areas of possible fringe interest? In addition, are there any professional organisations, societies, companies or other groups whose members/employees might be interested in the book? Do you have any recommendations regarding content that would ensure appeal to the intended market? In your opinion, is this book primarily a reference, text or monograph?

6. Are there any undergraduate and/or postgraduate courses in the UK, Europe, the USA or elsewhere for which the book might be adopted as a main course text or recommended for supplementary reading? Please give details of courses together with information on texts currently in use which might be considered as competitors.

7. Do you know of any existing publications on this subject or manuscripts in preparation which are likely to compete with the book under review? Please supply details and compare principle features.


8. Could you suggest possible additional referees? (Please provide full addresses and/or telephone numbers where possible)
9. Are there any additional comments you wish to make concerning the proposed book?
10. In the event of any discussion of your comments with the author(s) and/or editor(s), do you have any objection to the disclosure of your identity, or would you prefer to retain reviewer's anonymity?

Thank you for taking the time to complete this questionnaire.

Once again, many thanks for reviewing this book proposal. Please complete the details listed below before returning the completed questionnaire to Wiley.

Tel: ...................................................................
Fax: ...................................................................
E-mail: ...............................................................
Date questionnaire was completed: ........................

Please indicate whether you would be prepared to review future proposals in this subject area. Yes [ ] No [ ]

In return for my comments on this proposal I would prefer to receive:

[ ] A book(s) up to the value of 75.00/$100.00 from the Wiley list.

Please send me the following catalogue(s):

1. Life Sciences, Medical Sciences and Related Areas [ ]
2. Earth Sciences and the Environment [ ]
3. Chemistry [ ]
[ ] Please send me the following Wiley book(s) to the value of 75.00/$100.00
(Please include author, title and ISBN)

Please return the completed questionnaire, if possible by 26th April 2002, to:

Charlotte Brabants
Senior Publishing Editor
Life and Medical Sciences

John Wiley & Sons
4th Floor, International House
Ealing Broadway Centre
London W5 5DB
0208 326 3842
0208 326 3801 FAX