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AUTOHEMO, DANGER OF CITRATED BLOOD, SUBCONJUNCTIVAL - 65F1
Bacskulin and Bacskulin [65F1] reported good results with subconjunctival autohemotherapy in corrosions of the eye, injecting "1.5 to 2.0 cc of fresh blood into the perilimbal and fornix region as quickly as possible." However, they warned against the use of citrated blood: "It is especially important that no citrated blood be used. After citrated blood, almost all cases show heavy vascularization with corneal leukoma, and often a pointed deformity of the lid. In contrast, the control eye treated with fresh blood of the patient and the recommended additional therapy always shows satisfactory end results.
"This can be explained by the fact that, when calcium is combined with the acids of mucopolysaccharides and extracted by sodium citrate, a new complex (CaNaCitrate) is formed. ... However, because CaNaCitrate is almost water insoluble, it cannot diffuse out of the corneal tissue, and so remains in the corroded corneal parenchyma as a foreign body."