ADMINISTRATION OF ANTIBODY FOR POLIOMYELITIS  [48R4-274]


  We may note that in the treatment of acute poliomyelitis, Dr.


Rosenow used relatively large, single applications of large


quantities of antibody, as compared to his work a decade later with


multiple sclerosis, wherein repeated smaller doses were used:


  " ... Only one therapeutic, intramuscular, or subcutaneous


injection of artificial antibody was given to each patient.  This


usually consisted of 2 ml. of the solution of antibody from 5


billion streptococci for children 5 years of age or younger and two


additional milliliter for each additional year of age up to 21


years4.  A truly remarkable diminution of antigen and increase in


antibody uniformly occurred in from one to three hours after the


injection and remained at low and high level respectively for 24 or


48 hours or longer.  control injection of NaCl solution had no


apparent effect. ... Of the 26 patients each receiving one


therapeutic injection of the 'poliomyelitic' streptococcal


antibody, 19 showed clinical improvement ... . No clinical change


attributable to the injection of antibody occurred in seven ..."


[48R4-274]