ULCERATIVE COLITIS   30R9
SERUM SICKNESS, HOW TO AVOID  30R9
  Bargen, JA, EC Rosenow and GFC Fasting, Archives of Internal
Medicine, 1039-1047, "Serum treatment for chronic ulcerative
colitis" [30R9], discussed the alteration of immune serum so as
to avert serum sickness reactions while preserving beneficial
attributes.  This was accomplished by dilution in ether water
which causes the precipitation out of a modified euglobulin
containing essential antibodies, which is then preserved in
glycerin-salt solution.  This antibody euglobulin solution was
administered in approximately 200 cases, given deeply in the
muscles.  Reporting specifically on the first 50 consecutive
cases: "Twenty-four patients became free from symptoms; thirteen
became from 75-90 percent well, and six were improved at least 50
percent.  In only seven cases was there little if any change
following the treatment.  These seven cases were either severe,
long-standing cases with extensive involvement of the colon and
destruction, or there were serious complications, such as
multiple polyps or strictures."
  "Certain factors seemed to have a bearing on recurrence of
symptoms after patients become clinically well.  One of the
significant features seemed to be the failure to remove possible
foci of infection."
  Please note that Dr. Rosenow was later able to fully avoid any
potential negative effects of "immune serum" through the
preparation of "thermal antibody", which was successfully
employed therapeutically in a wide range of diseases.  (see also
58R1).