GLYCEROL-NACL SUSPENSION OR DIRECT BACTERIA IN VACCINES  29R1-506


  Dr. Rosenow relates how vaccines are made from either directly


from unwashed sedimented bacteria "or at various intervals from


those preserved in dense suspension in glycerol, two parts, and


saturated sodium chloride solution, one part."   29R1-506


  The preservation of streptococci in glycerol-NaCl menstruum  and


preferencial use of such streptococci in vaccines was to become


standard operating procedure for Dr. Rosenow.  [see: 48R2-371,


50R1-120, 45R4-163, 51R4-610, 34R3-407]






SYMPTOMLESS FOCI, IMPORTANCE OF  29R1-506 


  "The causative streptococcus often was isolated not only from


badly infected tonsils but from tonsils that appeared small and


normal but which on removal were large and sometimes contained


abscesses, from unsuspected remnants of tonsils, and from


syumptomless roentgenographically positive and negative pulpless


teeth, root tips and residual areas which had not been considered


previously or which were thought to be harmless." 29R1-506


     - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -


Foci of infection in tonsils, teeth, pulpless teeth  29R1-506


   Diseases:   


encephalitis           70%     56%      87%


arthritis              51      69       61


torticolis             60      75       76


MS                     78      67       89


chronic polio          65      71       92


gastroduod.ulcer       74      74       52


lesions of eye         53      53       50


lesions of skin        74      56       77


prostatitis            63      54       69






FAVORABLE RESULT AFTER BOTH FOCUS REMOVAL AND VACCINE   29R1-510


Rosenow responded to Holman's fraudulent "critical review" in a


gentlemanly fashion, and then provided summary data for 358 cases


of various diseases, comparing results where vaccines were or not


used, and foci were or were not removed  29R1


        All foci removed All foci not removed


Vaccine  (% improved)        (% improved)


-Used:         61                 25


-Not used:     54                 21






REMOVAL OF FOCI NECESSARY EVEN WITH SPECIFIC VACCINE  29R1-511


"Since streptococci appear to be a cause of so many diseases, since


immunity is of short duration, and since mechanical factors play so


large a part in maintaining infection in structures so commonly the


seat of foci, even after prolonged use of specific vaccines,


mechanical correction or removal, so far as possible, will probably



always be necessary even if highly effective specific or other


remedial agents are discovered.  Recurrence of the previous


condition or new localizations are prone to occur unless the


predisposing cause, the focus, is eliminated.  Likewise, operation


will probably always be indicated in many of the chronic systemic


lesions, such as chronic indurated ulcer, cholecystitis with


gallstones, and appendicitis with fecal stones or constricted lumen


from previous attacks.






DOSAGE, ALLERGY   29R1-511


ALLERGY, DOSAGE   29R1-511


  "Considerable evidence has been obtained in this study which


suggests that tissues in the cases of various chronic diseases,


particularly the diseased tissues, become hypersensitive to the


infecting organisms and their toxic products, as indicated by


exacerbations which are particularly prone to occur following too


strenuous or incomplete removal of foci of infection, and by the


reactions which sometimes follow injection of autogenous vaccines,


a point stressed by Kolmer.  If the dosage of vaccine is gagued so


that the local and constitutional reactions are relatively slight


the tolerance may often be greatly increased, even tenfold, and the


patient improves, a result in accord with that of Wherry and others


in bronchial asthma.  If the dosage is too large tolerance may not


increase but actually diminish, reactions may become progressively


more marked with each succeeding injection and the patient's


condition grow worse.  This narrow limit of effective dosage


determined more by the reaction in the patient than by the number


of bacteria and the use, without bacteriologic diagnosis, of stock


vaccines made from bacteria long cultivated in the laboratory have,



we believe, contributed much to the general disrepute into which


vaccine therapy has unfortunately fallen."