ULCER, INFECTIOUS ORIGIN OF  - HISTORICAL PRECEDENTS- 16R8-334


  "The infectious origin of ulcer, while not generally accepted,


has had adherents for many years."  Dr. Rosenow recounts various


studies from 1857 involving the experimental production of stomach


ulcer following intravenous injections of various organisms, and


demonstrations from 1874 of bacteria in edges and floors of ulcers,


which bacteria generally had been considered secondary invaders. 


Dr. Rosenow asserts "It is a well known fact that ulcer in the


stomach in man occurs not infrequently during severe or fatal


infections of various kinds, particularly streptococcal infections.


... Bolton [Ulcer of the Stomach, 1913, p. 59] states that probably


sthe commonest cause of necrosis of the mucous membrane and


resulting acute ulcer of the stomach is bacterial infection, that


the infection occurs through the blood stream, and that the


necrosis is due to the direct effect upon the tissues of the


bacterial poison, alone or together with the gastric juice."






STOMACH ULCER CAUSED BY STREPTOCOCCI IN BLOOD 16R8-335


  "The supposed relation between infected tonsils or gums and


gastric ulcer may be due not to the swallowing of bacteria, as is


usually supposed, but to the entrance into the blood of


streptococci of the proper kind of virulence to produce a local


infectyion in the wall of the stomach.  Many other observations may


be cited, such as associated infections of the gall bladder and


appendix, which suggest that gastric ulcer may be due to


streptococci."






SEASONALITY OF STOMACH ULCERS IN MALE HUMANS  16R8-356


"Since streptococci from certain foci of infection in patients with


ulcer tend to produce ulcer of the stomach in animals, might not


the frequency of ulcer in the male sex, in certain localities, and


during the winter months, be best explained on the basis of a high


incidence of throat and other infections?  Such infections would


afford opportunity for streptococci to acquire affinity for the


stomach and to gain entrance into the blood stream."   






ALKALINITY AND ULCER THERAPY: LOCAL OR SYSTEMIC ACTION?  16R8-357


  "Some ulcers in man may be made to heal when the acidity is


reduced by the administration of alkalies, as advocated especially


by Sippy, or by the alkaline contents of the duodenum, following


gastroenterostomy.  Might not the good effect be due partly to an


alkalization of the tissues throughout the body, rather than wholly


to local action?"






ULCER, PROOF OF CAUSE OF   16R8-359


  "The occurrence of acute ulcer of the stomach and exacerbations


of the symptoms in chronic ulcer in connection with foci of


infection; the improvement in symptoms following removal of foci of


infection; and the development of new ulcers after excision of


ulcer in patients in whom chronic supprating foci have not been


removed - all strongly suggest the etiologic relation between


remote foci of infection and ulcer.  None of these observations,


however, prove the etiology of the ulcer.  The demonstration of


streptococci in foci of infection in patients with ulcer and in the


ulcers themselves, and the fact that they localize in the stomach


in animals, furnish what seems to me to be the final proof of the


etiology."