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AUTOSEROTHERAPY: IV vs IM 16H6
Robertson [16H6] expressed a preference for IV injections: "Studies in anaphylaxis have shown the vastly greater susceptibility of an animal to intravenous injections than to those given subcutaneously or intramuscularly. ... It seem possible that ... when we inject subcutaneously, or especially intramuscularly, prompt reactions and beneficial results follow only in cases in which by chance we happen to enter a vein."